If you have been paying attention to conversations in aesthetic medicine recently, you will have noticed a term appearing with increasing frequency. Polynucleotides. And with it, a specific treatment that has become one of the most discussed and sought-after skin interventions available: Rejuran.
Here is what it actually is, how it works and whether it might be relevant to your skin.
What Are Polynucleotides?
Polynucleotides are naturally occurring biological molecules made up of long chains of nucleotides, the building blocks of DNA and RNA. In the context of aesthetic medicine, polynucleotides used in treatments are typically derived from salmon DNA, which shares a high degree of compatibility with human genetic material.
When introduced into the skin, polynucleotides act as a signalling and repair agent, working with the skin's own cellular processes to support regeneration, improve hydration and enhance overall skin quality from within.
Unlike many aesthetic treatments that introduce a foreign substance to create a structural change, polynucleotides work biologically, supporting the skin's own capacity to repair and renew itself. This is what makes them particularly relevant to the growing conversation around regenerative aesthetics and skin longevity.
What Is Rejuran?
Rejuran is a specific polynucleotide-based skin treatment originally developed in South Korea and now widely used in aesthetic clinics globally. It is administered as a series of small injections delivered into the skin, typically across the face, neck, under-eye area and décolletage.
The treatment works by delivering a concentrated infusion of polynucleotides into the dermis, where they stimulate fibroblast activity, support collagen and elastin production and improve the skin's overall hydration, texture and resilience. The results develop gradually over a course of treatments and tend to feel very natural, which is a significant part of its appeal.
Rejuran is not a filler. It does not add volume or alter the structural appearance of the face. It works at the level of skin quality, improving the underlying health and integrity of the skin rather than making surface-level changes.
What Can Rejuran Help With?
Rejuran is particularly well suited to addressing skin quality concerns that go beyond what topical skincare can reach. These include overall skin texture and hydration, fine lines and skin crepiness, dullness and loss of skin vitality, the appearance of pores and overall skin resilience.
It is also increasingly used as a preventative treatment for those in their thirties who want to support skin quality before more visible signs of ageing appear, and as a complementary treatment alongside other modalities in a broader skin rejuvenation plan.
At All Saint Clinic, Rejuran is recommended and administered exclusively by our qualified Aesthetic Doctors, always following a thorough consultation to assess suitability and discuss expected outcomes.
How Is Rejuran Different from Other Skin Treatments?
Rejuran is often discussed alongside skin booster treatments, and while they share the goal of improving skin quality from within, there are meaningful differences.
Traditional skin boosters typically use hyaluronic acid to deliver deep hydration and improve skin plumpness and texture. They are effective, well-established and widely used.
Rejuran, by contrast, uses polynucleotide technology which works at a cellular level to support the skin's own repair and regeneration processes. Where skin boosters primarily improve hydration and surface quality, Rejuran also supports the underlying biological function of the skin. Many patients and clinicians consider this a more foundational approach, particularly within the context of a skin longevity programme.
In practice, the two treatments are often complementary, and your Aesthetic Doctor will advise on the most appropriate approach or combination based on your individual skin and goals.
What to Expect
Rejuran is administered as a series of small injections across the treatment area. Most patients describe the experience as manageable, with mild discomfort that settles quickly. Temporary redness or swelling at the injection sites is common and typically resolves within a short period.
Results from Rejuran develop gradually over several weeks as the polynucleotides begin to support cellular activity within the skin. A course of treatments is typically recommended for the most meaningful outcome, with a maintenance schedule discussed during your consultation.
Is Rejuran Right for You?
Rejuran may be worth exploring if you are looking to improve overall skin quality, texture and hydration through a biologically driven approach, if you are interested in a regenerative treatment that works with your skin rather than making structural changes, or if skin longevity is a central part of how you approach your aesthetic health.
As with all treatments at All Saint Clinic, suitability is assessed during a thorough consultation with one of our Aesthetic Doctors. We do not believe in a one-size-fits-all approach to any treatment, and Rejuran is no exception.
